La chiesa cattolica di Shangai è stata fondata nel 1608 quando Paul Xu Guangqi, primo cattolico di Shangai, invitò il gesuita italiano Lazzaro Cattaneo a predicare nella città. Circa 200 persone ricevettero il battesimo durante i due anni di permanenza del missionario; la prima chiesa cattolica fu costruita nei pressi di Xujiahui, dove oggi si trova la cattedrale.
A member of a noble family in Sarzana near Genoa , Italy , Cattaneo entered the Society of Jesus at Rome in 1581. After completing his training in Portugal , he went to Goa , India , and in 1589 became superior of the mission on the Fishery Coast . In 1593 he arrived in Macao to study Chinese and the following year was with Matteo Ricci in Shao-chou (Shaoguan). As interim superior of that mission, Cattaneo was the first to discuss Christianity with Hsu Kuang-ch'i, one of the pillars of the early church in China .